

Prompt Action
Assured Control
Fixed Dose Combination therapy:
MONTEL ®: LEVOCETIRIZINE 5MG + MONTELUKAST 10MG MONTEL ® DT: LEVOCETIRIZINE 4MG + MONTELUKAST 2.5MG
Mode of Action

i. LEVOCETIRIZINE
A selective, second generation H1 histamine antagonist.
Prevents smooth muscle contraction, increased permeability of vascular endothelium, histidine uptake in basophils, stimulation of cough receptors, and stimulation of flare responses in the nervous system.
Goes beyond merely H1 antagonism:

ii. MONTELUKAST
Binds with high affinity and selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor , CysLT1, in airways. This prevents airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.
INDICATIONS AND POSOLOGY
Adults (MONTEL ®) and children (MONTEL ® DT): One tablet once daily for treatment of
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1. Seasonal and perennial allergic rhinitis.
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2. Asthma:
• Add on therapy for asthma and allergic rhinitis. • Prophylaxis of exercise-induced asthma (EIB): Two hours before exercise.)
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3. Chronic idiopathic urticaria
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MONTEL ® UNIQUE CLINICAL FEATURES
- Favorable safety profile (Pregnancy category B) and well tolerated.
- Montelukast, an alternative anti-inflammatory medications in the management of chronic asthma and exercise-induced bronchospasm (EIB)
- Levocetrizine, active R enantiomer of cetirizine that exhibits two fold increase in affinity for H1 receptors over cetrizine.
- Levocetrizine, potent antihistamine (than Loratidine, ebastine, fexofenadine and mizolastine).
- Based on adequate and well–controlled clinicalstudies Rupatidine is not superior or does not work any better than Levocetrizine.
- Efficacious and improves quality of life than individual drugs given alone.